In vitro and in silico analysis for acetylcholinesterase (AChE) inhibitors of some seaweed: Insights into their biological activity

Document Type : Original Article

Authors

1 Asmaa Fahmy St. Heliopolis

2 Gesr EL-Suez, Cairo, Egypt

Abstract

Marine algae, unlike terrestrial plants, produce biologically active molecules as a defense mechanism against the adverse environment in which they live and may include various physiologically active substances with medical benefits. The phytochemical contents of Ulva lactuca and Corallina officinalis in various solvents are examined in this paper. The aqueous extract of seaweed was studied for antioxidants, antibacterial, antibiofilm, anticancer, and anti-Alzheimer effects, as well as best-pose compounds for their interaction against acetylcholinesterase (AChE-targeted) Alzheimer disease (AD). U. lactuca extract had the highest inhibitory efficiency against all bacterial biofilms when compared to C. officinalis, and it had better antibacterial activity against Gram-positive bacteria than Gram-negative bacteria. U. lactuca had greater anticancer activity against hepatic carcinoma (HepG-2) compared to C. officinalis, with IC50 values of 182 ± 4.61 µg/ml and 222 ± 5.98 µg/ml, respectively. The last one was the most effective in inhibiting AChE, with an IC50 of 319.1 ±1.045 μg/ml. In GC-MS analysis of C. officinalis, the most concentration compounds found were found, there were five, were studied in molecular docking with AChE. The result was the Tricyclo most effective of the AChE domain binding conformation with a binding energy of -5.7 kcal/mol and 7 hydrophobic residues which may be effective in treating Alzheimer disease.

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